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KMID : 0390020100200030173
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Pediatric Allergy and Respiratory Disease
2010 Volume.20 No. 3 p.173 ~ p.178
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Association of Vitamin D Status with Acute Lower Respiratory Infection in Children
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Kim Young-Jae
Lee Ju-Seok
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Abstract
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Background:Acute lower respiratory tract infection (ALRI) is a common disease in children. Micronutrient deficiencies may increase the risk of ALRI. The aim of this study is to determine the association of vitamin D status with susceptibility to ALRI by comparing serum 25 hydroxy-vitamin D [25(OH)D] levels between a group of young children under 5 years of age with ALRI and healthy children.
Methods:Serum 25(OH)D concentrations were measured in patients under 5 years of age admitted to hospital with a diagnosis of pneumonia (n=40) or bronchiolitis (n=34) from October 2009 to December 2009 as well as in healthy patients of similar age without respiratory symptoms (n=54). Serum 25(OH)D concentrations were measured by electrochemileuminescence immunoassay.
Results:The mean serum 25(OH)D level were similar between the ALRI and control groups (28.4±9.0 versus 29.1±7.1 ng/mL). There was no significant difference in the prevalence of 25(OH)D insufficiency between the 2 groups at 2 thresholds (for <15 ng/mL, 8.1 vs. 5.6%; P =0.19, and for <30 ng/mL, 59.5 vs. 64.8%; P =0.75).
Conclusions:In our study, no difference was observed in vitamin D levels between the ALRI and control groups. Therefore, Vitamin D status may not be associated with the risk of hospitalization for ALRI in children.
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KEYWORD
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Vitamin D, Pneumonia, Bronchiolitis
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